Professor Thomas Jaki

Evaluating differential effects using regression interactions and regression mixture models
Van Horn, M.L., Jaki, T., Maysn, K., Howe, G., Feaster, D., Lamont, A.E., George, M., Kim, M. 08/2015 In: Educational and Psychological Measurement. 75, 4, p. 677-714. 38 p.
Journal article

A practical design for a dual-agent dose-escalation trial that incorporates pharmacokinetic data
Cotterill, A., Lorand, D., Wang, J., Jaki, T. 15/06/2015 In: Statistics in Medicine. 34, 13, p. 2138-2164. 27 p.
Journal article

Adaptive clinical trials in tuberculosis: applications, challenges and solutions
Davis, G.R., Phillips, P.P., Jaki, T. 1/06/2015 In: International Journal of Tuberculosis and Lung Disease. 19, 6, p. 626-634. 9 p.
Journal article

Multi-arm clinical trials with treatment selection: what can be gained and at what price?
Jaki, T. 04/2015 In: Clinical Investigation. 5, 4, p. 393-399. 7 p.
Journal article

Statistical approaches for the determination of cut points in anti-drug antibody bioassays
Schaarschmidt, F., Hofmann, M., Jaki, T., Gruen, B., Hothorn, L.A. 03/2015 In: Journal of Immunological Methods. 418, p. 84-100. 17 p.
Journal article

A review of statistical designs for improving the efficiency of phase II studies in oncology
Wason, J., Jaki, T. 2015 In: Statistical Methods in Medical Research. 12 p.
Journal article

Impact of an equality constraint on the class-specific residual variances in regression mixtures: a Monte Carlo simulation study
Kim, M., Lamont, A.E., Jaki, T., Feaster, D., Howe, G., Van Horn, M.L. 2015 In: Behavior Research Methods. 14 p.
Journal article

Some recommendations for multi-arm multi-stage trials
Wason, J., Magirr, D., Law, M., Jaki, T. 2015 In: Statistical Methods in Medical Research.
Journal article

Telmisartan and Insulin Resistance in HIV (TAILoR): protocol for a dose-ranging phase II randomised open-labelled trial of Telmisartan as a strategy for the reduction of insulin resistance in HIV-positive individuals on combination antiretroviral therapy
Pushpakom, S.P., Taylor, C., Kolamunnage-Dona, R., Spowart, C., Vora, J., Garcıa-Finana, M., Kemp, G.J., Whitehead, J., Jaki, T., Khoo, S., Williamson, P., Pirmohamed, M. 2015 In: BMJ Open.
Journal article

Flexible sequential designs for multi-arm clinical trials
Magirr, D., Stallard, N., Jaki, T. 30/08/2014 In: Statistics in Medicine. 33, 19, p. 3269-3279. 11 p.
Journal article

A comparison of methods for classifying samples as truly specific with confirmatory immunoassays
Jaki, T., Lawo, J., Wolfsegger, M.J., Allacher, P., Horling, F. 25/01/2014 In: Journal of Pharmaceutical and Biomedical Analysis. 88, p. 27-35. 9 p.
Journal article

A hybrid method to estimate the minimum effective dose for monotone and non-monotone dose-response relationships
Wolfsegger, M.J., Gutjahr, G., Engl, W., Jaki, T. 2014 In: Biometrics. 70, 1, p. 103-109. 7 p.
Journal article

Designing multi-arm multi-stage clinical studies
Jaki, T. 2014 In: Developments in statistical evaluation of clinical trials. Berlin : Springer p. 51-69. 19 p.
Chapter (peer-reviewed)

Statistical evaluation of toxicological assays with zero or near-to-zero proportions or counts in the concurrent negative control group: a tutorial
Jaki, T., Kitsche, A., Hothorn, L.A. 2014 In: JP Journal of Biostatistics. 11, 1, p. 1-32. 32 p.
Journal article

Authors' reply to comments on "Estimation in AB/BA cross-over trials with application to bioequivalence studies with incomplete and complete data settings"
Jaki, T., Pallmann, P., Wolfsegger, M.J. 30/12/2013 In: Statistics in Medicine. 32, 30, 2 p.
Comment/debate

Estimation in AB/BA cross-over trials with application to bioequivalence studies with incomplete and complete data designs
Jaki, T., Pallmann, P., Wolfsegger, M.J. 30/12/2013 In: Statistics in Medicine. 32, 30, p. 5469-5483. 15 p.
Journal article

Statistical evaluation of toxicological assays: Dunnett or Williams test? − take both
Jaki, T., Hothorn, L.A. 11/2013 In: Archives of Toxicology. 87, 11, p. 1901-1910. 10 p.
Journal article

Planning multi-arm screening studies within the context of a drug development programme
Wason, J., Jaki, T., Stallard, N. 10/09/2013 In: Statistics in Medicine. 32, 20, p. 3424-3435. 12 p.
Journal article

Differential effects of parental controls on adolescent substance use: for whom is the family most important?
Fagan, A.A., Van Horn, M.L., Hawkins, J.D., Jaki, T. 09/2013 In: Journal of Quantitative Criminology. 29, 3, p. 347-368. 22 p.
Journal article

Multiplicity: discussion points from the PSI multiplicity expert group
Phillips, A., Fletcher, C., Atkinson, G., Channon, E., Douiri, A., Jaki, T., Maca, J., Morgan, D., Roger, J.H., Terrill, P. 09/2013 In: Pharmaceutical Statistics. 12, 5, p. 255-259. 5 p.
Journal article

Analysing malaria drug trials on a per individual or a per clone basis: a comparison of methods
Jaki, T., Parry, A., Winter, K., Hastings, I. 30/07/2013 In: Statistics in Medicine. 32, 17, p. 3020-3038. 19 p.
Journal article

Designing exploratory cancer trials using change in tumour size as primary endpoint
Jaki, T., Andre, V., Su, T., Whitehead, J. 10/07/2013 In: Statistics in Medicine. 32, 15, p. 2544-2554. 11 p.
Journal article

Principles of dose finding studies in cancer: a comparison of trial designs
Jaki, T., Clive, S., Weir, C. 05/2013 In: Cancer Chemotherapy and Pharmacology. 71, 5, p. 1107-1114. 8 p.
Journal article

Uptake of novel statistical methods for early phase clinical studies in the UK public sector
Jaki, T. 04/2013 In: Clinical Trials. 10, 2, p. 344-346. 3 p.
Journal article

Considerations on covariates and endpoints in multi-arm multi-stage clinical trials selecting all promising treatments
Jaki, T., Magirr, D. 30/03/2013 In: Statistics in Medicine. 32, 7, p. 1150-1163. 14 p.
Journal article

Finite mixtures for simultaneously modelling differential effects and non-normal distributions
George, M., Yang, N., Jaki, T., Feaster, D., Lamont, A.E., Van Horn, M.L., Wilson, D.K. 2013 In: Multivariate Behavioral Research. 48, 6, p. 816-844. 29 p.
Journal article

Simultaneous confidence intervals that are compatible with closed testing in adaptive designs
Magirr, D., Jaki, T., Posch, M., Klingelmueller, F. 2013 In: Biometrika. 100, 4, p. 985-996. 12 p.
Journal article

Using regression mixture models with non-normal data: examining an ordered polytomous approach
George, M., Yang, N., Van Horn, M.L., Smith, J., Jaki, T., Feaster, D., Maysn, K., Howe, G. 2013 In: Journal of Statistical Computation and Simulation. 83, 4, p. 757-770. 14 p.
Journal article

Optimal design of multi-arm multi-stage trials
Wason, J., Jaki, T. 30/12/2012 In: Statistics in Medicine. 31, 30, p. 4269-4279. 11 p.
Journal article

A novel phase I/IIa design for early phase oncology studies and its application in the evaluation of MK-0752 in pancreatic cancer
Whitehead, J., Thygesen, H., Jaki, T., Davis, S., Halford, S., Turner, H., Cook, N., Jodrell, D. 15/08/2012 In: Statistics in Medicine. 31, 18, p. 1931-1943. 13 p.
Journal article

Recovering Independent Associations in Genetics: A Comparison
Sperrin, M., Jaki, T. 08/2012 In: Journal of Computational Biology. 19, 8, p. 978–987. 10 p.
Journal article

A generalized Dunnett Test for Multi-arm Multi-stage Clinical Studies with Treatment Selection
Magirr, D., Jaki, T., Whitehead, J. 06/2012 In: Biometrika. 99, 2, p. 494-501. 8 p.
Journal article

Non-compartmental estimation of pharmacokinetic parameters for flexible sampling designs
Jaki, T., Wolfsegger, M.J. 2012 In: Statistics in Medicine. 31, 11-12, p. 1059-1073. 25 p.
Journal article

Not quite normal: Consequences of violating the assumption of normality with regression mixture models
Van Horn, M.L., Smith, J., Fagan, A., Jaki, T., Maysn, K., Hawkins, D., Feaster, D., Howe, G. 2012 In: Structural Equation Modeling. 19, 2, p. 227-249. 23 p.
Journal article

A formal comparison of different methods for establishing cut points to distinguish positive and negative samples in immunoassays.
Jaki, T., Lawo, J., Wolfsegger, M.J., Singer, J., Allacher, P., Horling, F. 15/07/2011 In: Journal of Pharmaceutical and Biomedical Analysis. 55, 5, p. 1148-1156. 9 p.
Journal article

Estimation of pharmacokinetic parameters with the R package PK.
Jaki, T., Wolfsegger, M.J. 05/2011 In: Pharmaceutical Statistics. 10, 2, p. 284-288. 5 p.
Journal article

Symmetric maximum kernel likelihood estimation.
Jaki, T., West, R.W. 02/2011 In: Journal of Statistical Computation and Simulation. 81, 2, p. 193-206. 14 p.
Journal article

Direct effects testing : a two-stage procedure to test for effect size and variable importance for correlated binary predictors and a binary response.
Sperrin, M., Jaki, T. 30/10/2010 In: Statistics in Medicine. 29, 24, p. 2544-2556. 13 p.
Journal article

Establishing bioequivalence in complete and incomplete data designs using AUCs.
Jaki, T., Wolfsegger, M.J., Lawo, J. 07/2010 In: Journal of Biopharmaceutical Statistics. 20, 4, p. 803-820. 18 p.
Journal article

Optimization, refinement and reduction of murine in vivo experiments to assess therapeutic approaches for hemophilia A.
Baumgartner, B., Jaki, T., Wolfsegger, M.J., Eder, B., Schiviz, A., Schwarz, H.P., Muchitsch, E.M. 07/2010 In: Laboratory Animals. 44, 3, p. 211-217. 7 p.
Journal article

Probabilistic relabelling strategies for the label switching problem in Bayesian mixture models.
Sperrin, M., Jaki, T., Wit, E. 07/2010 In: Statistics and Computing. 20, 3, p. 357-366. 10 p.
Journal article

Book review : Bioequivalence and statistics in clinical pharmacology.
Jaki, T. 04/2010 In: Journal of the Royal Statistical Society: Series A (Statistics in Society). 173, 2, 2 p.
Book/Film/Article review

Assessing systemic drug exposure in repeated dose toxicity studies in the case of complete and incomplete sampling.
Wolfsegger, M.J., Jaki, T. 12/2009 In: Biometrical Journal. 51, 6, p. 1017-1026. 10 p.
Journal article

Recording lectures as a service in a service course.
Jaki, T. 11/2009 In: Journal of Statistics Education. 17, 3
Journal article

A note on statistical analysis of organ weights in non-clinical toxicological studies.
Wolfsegger, M.J., Jaki, T., Dietrich, B., Kunzler, J.A., Barker, K. 10/2009 In: Toxicology and Applied Pharmacology. 240, 1, p. 117-122. 6 p.
Journal article

Non-compartmental estimation of pharmacokinetic parameters in serial sampling designs.
Wolfsegger, M.J., Jaki, T. 10/2009 In: Journal of Pharmacokinetics and Pharmacodynamics. 36, 5, p. 479-494.
Journal article

Assessing differential effects: Applying regression mixture models to identify variations in the influence of family resources on academic achievement.
Van Horn, M.L., Jaki, T., Maysn, K., Ramey, S.L., Smith, J.A., Antaramian, S. 09/2009 In: Developmental Psychology. 45, 5, p. 1298-1313. 16 p.
Journal article

A theoretical framework for estimation of AUCs in complete and incomplete sampling designs.
Jaki, T., Wolfsegger, M.J. 05/2009 In: Statistics in Biopharmaceutical Research. 1, 2, p. 176-184. 9 p.
Journal article

Using a problem-based approach to teach statistics to postgraduate science students : a case study.
Jaki, T., Autin, M. 05/2009 In: MSOR Connections. 9, 2, p. 40-47. 8 p.
Journal article

One- and two-stage design proposals for a phase II trial comparing three active treatments with control using an ordered categorical endpoint.
Whitehead, J., Jaki, T. 28/02/2009 In: Statistics in Medicine. 28, 5, p. 828-847. 20 p.
Journal article

Confidence Intervals for Ratios of AUC's in the Case of Serial Sampling : A Comparison of Seven Methods.
Jaki, T., Wolfsegger, M.J., Ploner, M. 01/2009 In: Pharmaceutical Statistics. 8, 1, p. 12-24. 13 p.
Journal article

Using Multilevel Mixtures to Evaluate Intervention Effects in Group Randomized Trials.
Van Horn, M.L., Fagan, A.A., Jaki, T., Brown, E.C., Hawkins, J.D., Arthur, M.W., Abbott, R.D., Catalano, R.F. 04/2008 In: Multivariate Behavioral Research. 43, 2, p. 289-326. 38 p.
Journal article

Book review: Applied Nonparametric Statistical Methods.
Jaki, T. 2008 In: Journal of Biopharmaceutical Statistics. 18, 2, p. 393-395. 3 p.
Journal article

Maximum kernel likelihood estimation
Jaki, T., West, R.W. 2008 In: Journal of Computational and Graphical Statistics. 17, 4, p. 976-993. 18 p.
Journal article

Simultaneous confidence intervals by iteratively adjusted alpha for relative effects in the one-way layout.
Wolfsegger, M.J., Jaki, T. 2006 In: Statistics and Computing. 16, 1, p. 15-23. 9 p.
Journal article

Estimation of AUC from 0 to Infinity in Serial Sacrifice Designs.
Wolfsegger, M.J., Jaki, T. 12/2005 In: Journal of Pharmacokinetics and Pharmacodynamics. 32, 5-6, p. 757-766. 10 p.
Journal article